Valley of Forgetting
Jennie Erin Smith
December 14, 2025
Jennie Erin Smith is a journalist who’s authored the book Valley of Forgetting. It’s about an extended rural Colombian family, with 6,000 members, in which early onset Alzheimer’s disease is endemic. Smith spent seven years in Medellin working on this.
The family’s cause of illness is a genetic mutation, which kills sufferers in the 45-50 age range. Smith’s main contact point was Dr. Francisco Lopera, a neurologist, who focused his career working on this particular problem. The effort was complicated by pervasive political violence in Colombia during the 1980s. Also part of the story was Dr. Ken Kosik, who identified the gene involved.
One family that Smith spent much time with had two girls whose mother died of the ailment at 49 —one of seven siblings, out of ten, who died before age 50. Smith noted that even many in the larger family who were spared the gene, and the illness, had their lives derailed by having to care for prematurely afflicted elders.
Dr. Lopera spearheaded a clinical trial, concentrating on this family, using a drug called Crenezumab, to see if it could prevent the onset of illness in people having the otherwise deadly mutation. There was hope that this work could also be helpful with regard to late-onset Alzheimer’s. Unfortunately, the trial ultimately failed.
However, meantime, they started seeing people having the mutation who did not get sick. It turned out that there was a separate mutation that counteracted the first one. Showing the complexity of the problem.
Fresh trials, with different drugs, are currently underway; and prelapsarian U.S. authorities in fact approved a medicine which does seem to combat Alzheimer’s symptoms. However, a problem for Colombian sufferers is that they can’t afford its stiff cost.
Recap prepared by Frank S. Robinson
